The 50-year-old star, who retired from the limelight after appearing at the Elle Women in Hollywood Awards in 2014, speculated that she had undergone a plastic surgery and recalled the "rather painful" moment in which she overheard strangers who negatively discussed her appearance.
During a performance on US radio station SiriusXM's "Jess Cagle Show," Zellweger said she was sitting next to two women and a man "on a subway in London" discussing celebrities.
"They talked about … how stupid Hollywood ladies are and especially about Renée Zellweger," she said.
Zellweger said they continued, "How could she do that, why should she leave?" and have an operation on the face as if we did not know it? It does not look like it itself, and you can not just do it where you go and do not look like you, because we expect you to look like yourself. "
She said the meeting made her stunned for a moment," I thought, 'Wow, that's interesting. Anyway, here's my stop. "" Even nastier when the man got up, looked up, and recognized her shortly before her stop.
"He said," Oh God, you are not, but you look just like you! " And I said, "Yeah, it's funny how that works, right?"
Zellweger insisted that the interaction served only as a reminder that she needed a positive attitude while being violated by public slapstick on life.
"It's only for a moment where you go, "God, wow, that's pretty painful." "But I do not live in it," she said, "It just visits my life here and there and I'm not really into the stuff until somebody sends it to me. I'm not looking for it.
"And I'm busy, you know, I have dogs and they have shots and they need pills twice a day, there's a lot, you know, I have other things to do."
Zellweger has previously denied the operation and stated that she "is leading a different, happier and more fulfilling life".
CNN has contacted Zellweger's representative to comment.