In a new study, scientists have investigated the relationship between fever and cancer incidence.
The recurrent patterns in patient reports suggest the existence of an inverse relationship between the history of infectious fever and the cancer risk that has been documented over decades of medical literature.
However, the evidence for this correlation is still primarily based on isolated cases.
The authors argue, based on previous research and experimental data, that repeated exposure to fever improves the ability of gd T cells to recognize cellular abnormalities and promote inhospitable environments (19659002) This work is the first to take the role recognize that gd-T cells can play as participants in this inverse relationship.
Infectious fever is the defense reaction that occurs when an organism's immune system comes into contact with exogenous pyrogens or pathogen-associated molecular patterns (PAMPs). Upon detection of these exogenous pyrogens, endogenous mediators ̵
The authors deepen the role of endogenous mediators such as cytokines
"In short, endogenous mediators of fever transmit metabolic substrates and energy to the immune system during fever, increasing the frequency of a variety of immune effects, including lymphocytes, the gd Authors report [19659002Exposuretoinfectionsincreasestheamountofantigeniccellsduringinfectionmayaccountfor45%ofthetotalamountoflymphocytesinthebloodVg9Vd2Tcelluptake
While previous research and current cancer immunotherapy practices focus primarily on alpha / beta (ab) T cells Focusing on the interaction between fever and Gd-T cells, B. could further investigate the greater impact and clinical benefits of this relationship.
The full results are in the journal "Quarterly Review of Biology"
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