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Researchers explain the link between alcohol, genes and heart failure



Washington: It turned out that strong links between heart health, genes, and alcohol were found.

According to a study by Imperial College London, researchers investigated flawed versions of a gene called titin, which is thought to be one in 100 people or 600,000 people in the UK after suggesting a new link between alcohol, genes and heart failure

Maintaining the elasticity of the heart muscle, and flawed versions are associated with a type of heart failure called dilated cardiomyopathy. New research now suggests that the defective gene might interact with alcohol to accelerate heart failure in some patients with the gene, even if they drink only modest amounts of alcohol.

In the first part of the study, the team analyzed 1

41 patients with a type of heart failure called Alcoholic Cardiomyopathy (ACM). This condition is triggered by drinking more than 70 units a week (about seven bottles of wine) for five years or more. In severe cases, the condition can be fatal or leave patients in need of a heart transplant.

The team found that the defective titin gene can also play a role in the condition. The study found that 13.5 percent of patients carry the mutation – much higher than the proportion of people who carry them in the general population.

These findings suggest that this condition is not simply due to alcohol poisoning, but from a genetic predisposition – and that other family members may also be at risk, said James Ware, study author. "Our research suggests that alcohol and genetics interact with each other – and genetic predisposition and alcohol consumption together can lead to heart failure.

At the moment, this condition is thought to be due to over-consumption of alcohol, but this research suggests this to patients should also be checked for a genetic cause – by asking for a family history and testing whether they are testing a fake titin gene and other genes that are associated with heart failure, "he said. He added that relatives of patients with ACM should receive assessment and heart scans – and in some cases have genetic tests to see if they unknowingly carry the faulty gene.

In a second part of the study, researchers explored whether alcohol might play a role in another type of heart failure called dilated cardiomyopathy (DCM). This condition causes the heart muscle to become stretched and thin and has a number of causes, including viral infections and certain medications. The condition may also be genetic, and it is believed that about 12 percent of cases of DCM are associated with a defective titin gene.

In the study, the team asked 716 patients with dilated cardiomyopathy how much alcohol they consumed. None of the patients consumed the high alcohol content needed to cause ACM. However, the team found that patients whose DCM was caused by the defective titin gene had moderately increased alcohol intake (defined as drinking above the recommended weekly limit of 14 units) and cardiac output.

Compared to DCM patients Those who did not consume excess alcohol (and whose condition was not caused by the defective titin gene) resulted in an excess of alcohol, leading to a 30 percent reduction in cardiac output. More research is now needed to examine how alcohol can affect people who carry the faulty titin gene but do not have heart problems, added Paul Barton, co-author of the study.

"Alcohol and the heart have a complicated relationship These findings suggest that alcohol in people with titin heart failure may worsen the condition.

" An important broader issue is also raised by the study: Are mutations in titin susceptible to humans? for heart failure when exposed to other things that affect the heart, such as cancer drugs or certain viral infections? That's something we want to actively tackle.

The study is published in the Journal of American College of Cardiology.


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