Washington: Lung cancer is the uncontrolled growth of abnormal cells that begin in one or both lungs; usually in the cells lining the airways.
One of the leading causes of preventable cancer death, lung cancer, is commonly thought to be due to smoking and multiple genetic variants.
One of these genetic components, a 15q25.1 chromosome, has previously been identified as a leading predictor of lung cancer susceptibility, smoking behavior, and nicotine dependence.
However, no previous study has documented the mechanisms of this leading agent or documented the sensitivity pathways that allow this chromosome to modify the development of the disease.
Now, a research team led by Xuemie Ji, MD, Ph.D., Research Associate at the Department of Biomedical Data Science at Dartmouth The Geisel School of Medicine helped solve the central problem by identifying two main pathways, which concerns the mechanism by which the chromosome 1
The first pathway is an interaction pathway in the nervous system that is linked to nicotine dependence. The other way can control key components in many biological processes, such as the transport of nutrients and ions and the human immune system.
"Our findings in metabolic pathways provide insights into the mechanism of lung cancer etiology and development that may shorten the interval between biological knowledge and translation for patient care," said Ji.
The study used two independent cohorts of 42,901 individuals with a genome-wide set of genetic variants, as well as an expression data set with lung tissue from 409 lung cancer patients to validate results.
Two different methods were used to analyze data and confirm that the results are reliable and can be repeated using a variety of methods.
Ji added, "The ability to block the harmful genetic variants downstream or parallel pathways could improve lung cancer prognosis and survival and therefore offer alternative strategies for treating such cancer."
The team works g, to identify more mechanisms contributing to increased lung cancer risk. They are intended to explain in more detail the great inexplicable division of lung cancer.
The full findings can be found in the journal Nature Communications.