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Researchers identify skin skin, loose fat and immunity



Microscopic image of skin reveals skin cells in blue and fat cells in green. The fat cell layer forms the final barrier against bacteria entering deep into the body. Credit: UC San Diego Health
    

Dermal fibroblasts are specialized cells deep in the skin that generate connective tissue and help the skin recover from injury. Some fibroblasts have the ability to convert into fat cells.
                                

Immunity on December 26, University of California San Diego School of Medicine researchers and colleagues show how fibroblasts develop into fat cells and identify the pathway that causes this process to cease as people age

"We have discovered that the skin loses its ability to form during aging," said Richard Gallo, MD, Ph.D., Distinguished Professor and chair of the Department of Dermatology at UC San Diego School of Medicine and Senior author on study.

Do not reach for the donuts. Gaining weight is not the pathway to converting dermal fibroblasts into fat cells since obesity thus interferes with the ability to fight infections. Instead, a protein that controls the growth of beta cells (TGF-β), stops dermal fibroblasts from converting into fat cells and prevents the cells from producing the antimicrobial peptide cathelicidin, which helps protect against bacterial infections.

"Aged dermal fibroblasts loose this ability and form fat under the skin," Gallo said. "Babies have a lot of this type of fat under the skin.

In TGF technology, the chemical composition of a human being is known to be "inhibited" by the skin.

β pathway, causing the skin to revert to a younger function and allowing dermal fibroblasts to convert into fat cells.

Staphylococcus aureus

Understanding the biological process that leads to an infection in the skin (S. aureus) -a pathogenic bacteria that is the leading cause of infections of the skin and heart and a major factor in worsening diseases, like eczema. Staphylococcus aureus or MRSA, which is a leading cause of death in the United States.

The long term goals and benefits of this research is to understand the infant immune system, Gallo said. Obesity, diabetes and autoimmune diseases.
                                                                


Explore further:
                                        Skin in the dermis lose their identity and function
                                    

More information:
Immunity (2018). DOI: 10.1016 / j.immuni.2018.11.003
                                        

Journal reference:
                                                                                                            Immunity
                                                        
                                                        
                                                                                                    

Provided by:
                                                                                                            University of California – San Diego
                                                        

                                                        
                                                                                                    


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