Increased glucose, transformed into energy, could give people with ALS improved mobility and a longer life,
Physicians have long known that people with ALS experience changes in their metabolism that often lead to rapid weight loss in a relentless cycle called hypermetabolism, according to University of Arizona-led research team.
People with ALS use more energy while resting, compared to those without the disease, the precise ingredient a body needs to make more energy. Experts have not known exactly what happens in a patient's cells to cause this dysfunction. "
Ernesto Manzo, who described the results, said:" This project is a way to parse out those details. " eLife as "truly shocking."
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The study revealed that when ALS-affected neurons are given more glucose, they turn that power source into energy. With that energy, they're going to survive longer and function better. Increasing glucose delivery to the cells, then, may be one way to meet the abnormally high energy demands of ALS patients.
"These neurons were finding some relief by breaking down glucose and getting more cellular energy," Manzo said. [1
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Previous studies on metabolism in ALS patients have reported Daniela Zarnescu, UA professor of molecular and cellular biology and senior author on the study.
"The fact that we uncovered a compensatory mechanism surprised me," Zarnescu said. "Thesis desperate, degenerating neurons revealed incredible resilience. Zarnescu said:
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"Scientists Find It Holds Molecule"
Manz said. "
In the lab, he and Zarnescu used high-powered microscopes to observe the motor neurons of fruit flies in their larval state, paying close attention to what has happened They provided more glucose.
They found that when they increased the amount of glucose, the motor neurons lived longer and moved more efficiently.
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Their findings were consistent with a pilot clinical trial, which found a possible intervention for ALS patients with gross metabolic dysfunction.
Reprinted from the University of Arizona
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