Reigns shocked the WWE Universe last Monday night when he revealed that he had been diagnosed with this terrible disease for the first time 11 years ago, and unfortunately, after a quick remission, the cancer has recently returned.
The big dog has taken a break to fight the disease, but that does not mean he will not perform.
ACE Comic Con announced that the four-time World Champion will be one of many celebrities attending one of their events next year on January 11 in Arizona.
The former Universal Champion will be accompanied by other WWE mega stars, such as five-time women's champion Alexa Bliss, seven-time women's champion Charlotte Flair and former ring announcer Lilian Garcia.
Many other celebrities are also present, including Marvel star Tom Hiddleston, Krysten Ritter and David Tennant.
Reigns is considered the next face of the WWE and has won 20 at the age of 1
Former WWE champion insists he does not go out of business Wrestling and Will return better than ever to prove that he can overcome any obstacle life throws at him.
The 33-year-old Grappler said: "Reality is my real name is Joe [Anoaʻi] and I've been living with leukemia for 11 years … and unfortunately it's back.
" And because the leukemia is back I can not fulfill my role I can not be the battlemaster and I will have to give up the Universal Championship.
"I will not lie, I'll take any prayer that you can send to me, but I'm not looking
" I'm not trying to make you feel bad because I have faith.
"When I was 22 years old, I was diagnosed with it and I was able to remorse it very quickly But I will not lie, that was the hardest time of my life
" I had no work, I had no money, I had no home and I had a baby is on the way. And the football was done with me.
"But do you know who gave me a chance? The team that gave me a chance was the WWE.
" After I'm done, the leukemia is another madness. "I'm coming home.
"I would like to show my family, my friends, my children and my wife that if life complains me with a curveball, I am the type of person standing in this batter's box, I will urge the plate, I will choke and I will swing for the fences every time! "