A new way of accurately introducing molecules into cells paves the way for safer drugs that are free of side effects. The researcher J. Julius Zhu and his colleagues have developed a way to manipulate molecules from compartment to compartment in single cells.
The same molecules do different things depending on their location, the researchers said. By manipulating the molecules, scientists can pinpoint where to aim, avoiding sites that cause harmful side effects.
"The problem with side effects is caused by the fact that you simply can not distinguish the molecules in the same cell," said Zhu.
"If you blocked a molecule, it blocked it, no matter what it did. And that usually has unwanted side effects. Almost every drug that can treat illnesses has big or small side effects, but usually they always have something, "he added. Read : Side effects of medications and adverse drug reactions ̵
So far, drugs have been targeting molecules very selectively, and if a molecule is considered harmful, researchers might try to develop a drug to completely block it.
But Zhu's new work highlights the flip side of this approach Problems cause because of what it does in one part of the cell, but at the same time the same molecule does something completely different in other parts.
So it would be like trying to solve the problem of congestion by: prohibiting cars.
Now, rather than trying hard to block a molecule, regardless of its many functions Doctors can target a specific molecule that does a specific thing at a specific location. This adds a new level of precision to the concept of precision medicine – medicine tailored to the needs of the patient.
Zhu and his research team believe that the technique will be useful for many different diseases, but especially for cancer and neurological disorders B. Autism and Alzheimer's.
Especially those who benefit from a better understanding of which molecules would achieve good targets in which places.
The technique will also accelerate the development of new treatments by allowing researchers to more quickly understand what molecules are doing and what should be targeted. "The idea [behind the technique] is actually very simple," added Zhu.
The study appears in the journal Neuron
Source : ANI
Source: Shutterstock  Published: July 8, 2018 14:39