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Scientists identify neurons that trigger aggression



London: Scientists have identified brain neurons that cause aggression, laying the groundwork for formulating new strategies to prevent damage from arousing such emotion.

According to the researchers, a group of neurons in the ventral prematal tube The hypothalamic nucleus (PMv) – an evolutionarily well preserved part of the brain that controls many of our fundamental drives – plays a key role in initiating and organizing aggressive behavior.

"Aggressive behavior and violence cause injuries and ongoing mental trauma to many people with costly structural and economic consequences for society, and our study supplements fundamental biological knowledge of their origins," said study leader Christian Broberger of Karolinska Institutet in Sweden.

Using a mouse model, researchers studied the ventral premammillary nucleus neurons. They were able to control the aggressive feeling in male mice by stimulating or inhibiting these cells.

The results published in the journal Nature Neuroscience showed that the neurons were more activated among the mice when they showed aggressive behavior when a new man was set up

By activating these neurons by optogenetics – using the neurons with Controlled light – they were able to initiate aggressive behavior in situations where animals would normally not attack, and disrupt sustained attack by inhibiting PMv. [19659002] The neurons could also activate other brain regions such as reward centers.

"We also found that the brief activation of PMv cells could trigger a lengthy outburst that could explain something we all recognize – like after a fight, the antagonism can last a long time," says Stefanos Stagkourakis of Karolinska Institutet ,

In an experiment by researchers It was also found that by inhibiting PMv cells in a dominant male and stimulating the same cells in a submissive male, they could invert their mutual hierarchical status.

"One of the most surprising findings in our study was that the role – switch we achieved by manipulating PMV activity during an encounter that lasted up to two weeks," added Broberger.

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