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To By Shamard Charles, MD, and Reuters
Scientists say you've taken a step to develop a potential diagnostic test for chronic fatigue syndrome, a condition caused by Fatigue and other debilitating symptoms is characterized.
Stanford University School of Medicine researchers said a pilot study of 40 people, half of them healthy and healthy Half of them had the syndrome and showed that their potential biomarker test correctly identified the ill people.
Chronic Fatigue Syndrome (CFS), also known as myalgic encephalomyelitis (ME), affects about 2.5 million people in the United States and America, affecting 1
Symptoms include overwhelming fatigue, joint pain, headache, and sleep disorders. There is no known cause or diagnosis yet, and the condition has left patients bed-safe or home-bound for years.
The study published in the Proceedings journal of the National Academy of Sciences on Monday analyzed blood samples from volunteers who used a "nanoelectronic assay" – a test that measured changes in minute amounts of energy as an indication of the health of immune cells and blood plasma become.
The scientists "highlighted" the blood samples with salt and compared the reactions. The results showed that all blood samples from CFS patients made a clear peak, while those from healthy controls remained relatively stable.
"We do not know exactly why the cells and the plasma work that way, even what they do," said Ron Davis, a professor of biochemistry and genetics who co-designed the study.
"(But) We see clearly a difference in how immune cells of healthy and chronic fatigue syndrome process stress. "
Other experts who were not directly involved in this work, however, indicated that there is still a long way to go before a biomarker is found that makes a CFS diagnosis and differentiates it from other diseases with similar symptoms can.
19659008] Simon Wessely, chair of psychiatry at the London Institute of Psychiatry at King's College Psychology & Neuroscience, who has worked with CFS patients for many years, said the study was the last of many attempts to create a biomarker to find CFS, but h Two key issues could not be resolved:
"The (first) problem is, can a biomarker differentiate CFS patients from patients with other tiring diseases? And second, does it measure the cause and not the consequence of disease? "He said in an e-mail message. "This study provides no proof that both have been achieved."
Andrew Lloyd, Professor of Infectious Diseases at the School of Medical Sciences of the University of New South Wales, Sydney, Australia, said it was premature to broaden conclusions on the study findings.
"It is premature to point out that this could be a" diagnostic biomarker for ME / CFS "because the sample size of patients was only 20 patients (and 20 healthy controls). This is very small for the validation of a new diagnostic test. Wessely also noted that doctors and patients should not be disillusioned by the results of the study.
"You do not need a blood test to prove that a disease exists, and the absence of such a test means." not even that everything is "in the head."