When it comes to fecal transplants, not all healthy bowel movements work the same. Researchers at the University of Auckland, New Zealand, re-examined a number of existing fecal grafting research and found that some donors were more crappy than others, according to a report released Tuesday in the journal Cellular and Infection Microbiology has been. ,
The so-called "super-poopers" produce a stool that is rich in the specific bacteria needed to restore the intestines of persons suffering from a range of conditions, such as ulcerative colitis and irritable bowel syndrome (IBS), which cause the For a disease necessary bacteria are missing Healthy Microbiome.
Justin O & Sullivan, senior author and adjunct professor of molecular biology at the University of Auckland, said that counting down on a super donor will help scientists understand why certain people have such a magical shit. [1
Feces grafts are what they sound like: they take that healthy bowel movement of one person and injection into the colon of the recipient. Transferring stool from one healthy person to another is an established treatment for Clostridium difficile or C diff, an infection that interrupts the production of healthy bacteria in the colon, causing abdominal pain and extreme diarrhea. Bacterial therapy works well in this condition as it kills the overgrowth of bad bacteria and replaces it with good ones. O & # 39; sullivan said fecal grafts can cure C diff (about 24 hours, up to a few weeks) quickly in about 90 percent of the time.
Fecal transplants have also been studied as a potential treatment for many obesity disorders (the O & # 39; sullivan currently under investigation), in mood disorders ranging to type II diabetes, to different results. Homogeneous feces transplantation became a viral trend in 2018. Some doctors commented on the risks they would try at home.
While studies have shown that C diff responds almost always well to stool transplantation, O & # 39; sullivan and its co-authors noted that under certain circumstances, such as ulcerative colitis, it was really of who the stool came from.
It turned out that some people have better feces than others.
Usually, donated feces are used to treat only one patient, but "super-poopers" have the superpower to help many people. "We are investigating whether we can treat a whole range of people with the same condition in a clinical trial. If the feces of one person heal several people, they are a super donor. "
The problem is that researchers are still not sure what constitutes a super-donor. O'Sullivan says it's more than just finding a healthy person. A super donor has a very diverse microbiome – many different types of healthy bacteria – and a strong immune system.
"You are not an individual – you are this wandering community [of bacteria]," said O & Sullivan. "Your microbiome is an interface between you and your environment. The best way to make your walking community [aka your microbiome] healthy is to eat lots of fiber, eat healthy, drink water, and exercise. "
But it's not just a healthy diet that makes a super pooper. Further research is needed to find out what makes a super donor. By examining super donors, scientists hope to isolate and identify which intestinal bacteria are most useful for certain conditions in order to personalize and standardize bacterial therapy.
Sullivan says his next team will try to predict the right super donors for a particular disease – they'll probably try it first in Crohn's disease.
"A transplant in the stool is the coarsest type of microbiome therapy," said O & Sullivan. "Ideally, we want to use a material that you have been telling for your entire life that you should stay away from it."