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Senior Scottish woman can hold keys to one of life's greatest tests



A 71-year-old Scottish woman can offer a miraculous way to reduce or eliminate pain in humans because she is amazing: she has never experienced physical pain.

Jo Cameron's body works like this She even did not realize how she burned herself until she burned her skin, CNN reports. She paid little attention to her remarkable capacity for a painless existence until the doctors discovered that she had severe hip replacement at the age of 65 – but had no pain at all. When she was 66, she had surgery on her hand, but she did not feel any pain after surgery. Cameron said, "Until just a few years ago, I had no idea that it was so unusual how little pain I feel, just thinking it was normal." It turned out that despite her painless joint degeneration to a severe joint degeneration.

A case study published Thursday in the British Journal of Anesthesia found that the researchers found that Cameron had mutations in her FAAH gene and her FAAH-OUT gene study:

One was a microdeletion in a pseudogene, previously mentioned only briefly in the medical literature and described by FAAH-OUT for the first time. In addition, she had a mutation in the adjacent gene that controls FAAH. Enzyme: Further testing by staff from the University of Calgary, Canada, showed increased blood levels of neurotransmitters that are normally broken down by FAAH, further demonstrating a loss of FAAH function.

The FAA The H gene has been frequently studied by scientists, but the FAAH-OUT gene has barely been studied.

Dr. Frances Williams, a professor of genomic epidemiology at King's College London, acknowledged that FAAH was "already the target of several clinical trials," but research on FAAH-OUT could be "a more effective method to treat a painkiller generate "[1

9659007] Devjit Srivastava, who studied Cameron and is co-author of the study, said: "The implications for these results are immense, and every second patient is still experiencing moderate to severe pain after surgery, despite advances in analgesics, and the findings suggest a novel analgesic discovery which may also provide postoperative pain relief and also accelerate wound healing, and we hope this can help the 330 million patients who are treated worldwide each year. "

James Cox, one of the study's leading researchers, added: "We found that this woman has a specific genotype that reduces the activity of a previously considered gene as a possible target for pain and anxiety treatments, and people with infrequent pain insensitivity can be valuable to medical research as we learn how their genetic Mutations affect pain perception Therefore, we would encourage anyone without pain to move forward. Now that we know how this newly identified gene works, we hope to make further progress in new treatment goals. According to the study, "Cameron" experiences very little anxiety and anxiety and may have improved wound healing due to the disorder, which researchers claim is that they could guide new treatments for a range of disorders. She adds: "She is an optimist who scored the lowest score on a standard scorching scale, and reports that she even in dangerous situations, like a younger one, never panics traffic congestion.

Cameron concluded, "I would be delighted if exploring my own genetics could help other sufferers. "


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