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Should you, your mother and your dog use CBD?

Illustration: Elena Scotti (Photos: Getty Images)

They are everywhere – in your supermarket, in the chain pharmacy, even in your local pet shop. The recent over-the-counter health trend for cannabidiol or CBD (the major component of cannabis that [19459009not makes you high) has produced a seemingly endless stream of new products and dubious health-related messages. 19659003] There is a lot of hype about CBD products that they are able to help with anxiety and help you fall asleep earlier, to lower the risk of dementia or the treatment of cancer. But what does science say about the health benefits of CBD? And how much should you look forward to buying a CBD burger or your dog with CBD treats?

For beginners, it is appropriate to clarify the confusing legal landscape in the US where CBD and cannabis exist.

"The real problem We do not have much science to transfer what we see in animals and laboratories to humans. "

The Federal Government has historically classified the cannabis plant and all its ingredients, including CBD, through the Drug Enforcement Agency. As a Schedule 1

drug, this means that it has no legal or medical use. However, at state level, exemptions have been made for the use of medicinal and recreational cannabis. Last June, the Food and Drug Administration also approved a CBD-derived drug, Epidiolex, to treat certain types of seizures. And last December, in its Farm Act, the government passed a provision that legalized the sale and cultivation of local hemp, a cannabis cultivated with less than 0.3 percent THC, the other major ingredient in cannabis, the responsible for his characteristic high.

Despite the legalization of hemp, the status of CBD as consumer goods remains bleak. The FDA issued a notice shortly after the adoption of the Farm Act, clarifying that it still had the power to regulate products with CBD regardless of their source. The agency also warned against approving the sale of CBD as an adjunct or being inactive as companies market their OTC products with specific health claims. The FDA has since sent warning letters to online retailers announcing these products for certain health benefits.

One particularly outrageous claim by the FDA, for example, is that CBD can help treat type 2 diabetes. While studies in mice suggested a potential benefit, the only apparently human study ever showed that CBD did nothing to address the key aspect of metabolic status – poorly controlled blood glucose levels – in actual patients.

This example highlights the most blatant error in CBD research. We do not know much about its effects, thanks in particular to the regulatory morass surrounding cannabis and its byproducts, which has slowed down research. What we know little, often comes from animal studies.

"Based on animal literature or what we call preclinical research, CBD appears to have a broad spectrum of therapeutic effects, from reduced inflammation to support for anxiety, pain or substance disorders." Ziva Cooper , Research Director of the Cannabis Research Initiative at the University of California, Los Angeles, opposite Gizmodo. "The real problem is that we do not have much science to transfer what we see in animals and laboratories to humans."

The majority of studies that examined CBD for pain also concluded THC. We know very little, if any, about the effects of CBD on pain when given by humans themselves.

This does not mean that CBD will not be more useful medically than some people already experience seizures. Nor should we ignore the experiences of people who claim that their chronic pain or anxiety has been alleviated with weed or products like CBD oil or creams. It just means we are on the verge of understanding the effects of CBD on health. And it is inevitable that some of the rosiest, farthest claims will disappear on closer scrutiny.

"What we do know is that certain high doses of CBD – 300 to 1,000 milligrams – have proven to be helpful indications, including schizophrenia and severe epilepsy disorders. And there is an indication that it could also help with anxiety, "Cooper said, referring to several studies and the approval of Epidiolex. Cooper and others are also conducting research into people who are investigating whether different cannabis strains (including those that contain mainly CBD) can better relieve pain than others and reduce the dosage of opioids required to treat this pain.

I tell the public that I study CBD for pain or as a substitute for opioids. Most people will say, do not we already know that? Do not we already have this data available? "Said Cooper. "But the truth is, we do not do it. In the majority of studies that examined CBD for pain, THC was also included. We know very little, if any, about the effects of CBD on pain when given by humans themselves. "

Despite this potential, there is another big problem when it comes to the trendy CBD-based products you're likely to see your box office is, according to Cooper. Even if a certain dose of CBD could help with your anxiety or insomnia, you certainly will not get so much with these products.

"CBD-infused foods or the solutions that you find in pharmacies across the country, will likely do this therapeutic does not contain 300 to 1,000 mg doses. They are likely to be much lower, about 10, perhaps 15 milligrams, and very far from a likely effective dose.

Were these products full of CBD, as different as they are When introduced to the body, whether eaten or applied to the skin, it can have a dramatic impact on how we respond to it. For example, topical antibiotics need to be formulated specifically to break through the hard skin layers to get into an infection, while nasal sprays can produce the effect of a drug faster than keeping a tablet under the tongue, and scientists are not sure how these differences would manifest themselves in CBD.

"We do not know how CBD will work with all these products – lotions, creams, edibles, suppositories," Cooper said.

Products marketed with CBD also have a problem For example, a 2017 study found that only 30 percent of products purchased online give how much CBD they had. Many mislabeled products had more CBD than advertised, which is not a big problem as there is probably no dosage that can seriously injure you. However, about a quarter did not have enough CBD, which essentially means you are taking a placebo.

For CBD products, submarking is not the only risk. Last year, the Centers for Disease Control and Prevention reported that more than 50 people in Utah were poisoned by counterfeit CBD products that actually contained synthetic cannabinoids. These cannabinoids are used to mimic the psychoactive effects of THC in the body, not CBD, but are more potent and can cause serious health problems, including hallucinations and psychotic episodes.

Contaminated CBD products are likely to be rare with these words. The legalization of hemp is likely to streamline and improve the security of the CBD market as a whole and accelerate research efforts. The FDA has also said it is beginning to develop a regulatory pathway that would allow the investigation and commercialization of CBD in food or consumer products without any legal burden. And states like Utah are creating their own regulatory system to legally sell and accurately label CBD products. In view of this, the CBD hype move will certainly move forward. Some finance experts estimate that it will become a billion dollar industry by 2020.

The science of CBD will take some time to catch up with this hype, but still. Cooper's hypothesis that CBD-heavy cannabis may reduce the need for potentially addictive opioids could soon be proven, but people are undoubtedly using CBD or cannabis just for this purpose. And while the FDA may minimize this type of vanity, it's difficult to explain to chronic pain patients with a few options that they need to absorb it and wait for a laminated seal of approval.

You are unlikely to put yourself and your loved ones in mortal danger by purchasing CBD-loaded biscuit or hemp supplements unless you use them to completely replace conventional medical treatments or completely ignore the advice of your doctors However, if you're an average person who wants to protect your wallet from hucksters selling useless CBD novelties, you should probably wait and see how science develops.

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