George Weah's office, forcing him to work from his private residence, the BBC has learned.
Press secretary Smith Toby told the BBC that on Wednesday two black snakes were found in the foreign affairs ministry building, site of the official office.
All staff have been told to stay away until April 22.
" It's just to make sure it crawls and creeping things get fumigated from the building, "Mr Toby said.
" The Ministry of Foreign Affairs hosts the office of the president, so it was an internal memo to ask the staff to stay home while they are the fumigation, "he said.
A FrontPage Africa newspaper video shows workers trying to attack the snakes when they appeared near the building's reception.
" The snakes were never killed, "Mr Toby said. "There's a little hole somewhere [through which] they made their way back."
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Police and security were seen guarding Mr. Weah's residence in the capital Monrovia. A fleet of vehicles including escorts jeeps were parked outside.
Mr Toby said the Ministry of Foreign Affairs has started to fumigate on Friday.
"That building's been there for years now, and [because of] the drainage system, the possibility of having things like snakes crawling in that building was high," he said.
Mr. Toby said.
The president is also returning to his official office on Monday after the fumigation.