Tokyo, 22.07. (PTI) The application of ultrasound waves to the entire brain can improve the dementia of cognitive functions and Alzheimer's disease, say scientists who conducted a study on mice.
The team led by Hiroaki Shimokawa of Tohoku University, Japan, found that the application of pulsed low intensity ultrasound (LIPUS) to the entire brain of the mice improved the formation of blood vessels and the regeneration of nerve cells with no obvious side effects ,
"LIPUS therapy is a non-invasive physical therapy that could be used for older high-risk patients without the need for surgery or anesthesia and could be used repeatedly," said Shimokawa.
Dementia affects approximately 50 million people worldwide, with 1
The cells that line the blood vessels of the brain are also tightly packed, forming a blood-brain barrier that prevents large molecules from crossing into the brain tissue. This restricts the types of drugs and cell therapies that could be provided for the treatment of dementia.
Researchers had conducted previous studies that demonstrated that LIPUS improves blood vessel formation in pigs with myocardial ischemia that reduces blood flow to the heart
Other studies have reported that LIPUS increases the production of proteins involved in survival and survival Growth of nerve cells are involved, in addition to a role in promoting nerve regeneration.
Focusing LIPUS treatment on a region of the brain called the hippocampus involved in memory has also been found to improve dementia in mice, but the details of how it does this need to be studied more closely ,
The team wanted to find out if the whole brain instead of focusing LIPUS is effective in treating mouse models of dementia, and if so, what happened at the molecular level to achieve this.
They found that cognitive impairment was significantly improved in mice treated with Konditides, similar to vascular dementia and Alzheimer's when LIPUS was applied to the entire brain for 20 minutes three times a day.
The mice with vascular dementia received treatment on the first, third, and fifth day after surgery, limiting the blood supply to the brain.
Mice with a condition simulating Alzheimer's disease in humans received 11 LIPUS treatments over a period of three months.
At the molecular level, genes have been activated in conjunction with the cells that lined blood vessels. In addition, the expression of an enzyme involved in the formation of blood vessels and a protein involved in survival and growth of nerve cells was increased.
The study published in the journal Brain Stimulation provides the first experimental evidence for LIPUS therapy in the whole brain improving cognitive dysfunction without serious side effects by improving specific cells associated with dementia pathology.
The first clinical trials evaluating the efficacy and safety of LIPUS treatment are already underway, researchers said. PTI MHN MHN
This is an unprocessed, unformatted lining from the Press Trust of India Wire.