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Epigenetics hopes for cancer



Eating organic foods without pesticides such as DDT and avoiding genetically modified foods may therefore be a good idea.

US biologist dr. Carol Lynn Curchoe warns that farmers are using "DNA mutation techniques such as intense beam explosion and toxic chemical baths"

Eliminating known carcinogenic activities, such as smoking tobacco products, can also help prevent genes from mutating.

Weinhold warns that burning fossil fuels to produce electricity genetically contributes to mutations that lead to cancer.

It also implies that decreasing dependence, if possible, on drugs is another way to alter the epigenetic expression of genes.

An alternative epigenetic therapy that differs from traditional chemotherapy and radiotherapy was discovered accidentally in South Africa decades ago by the Cape Town-born Peter Jones

says the Cancer Association's SA health chief Prof. Michael Herbst Epigenetics is investigating complex changes in organisms that are caused by altering gene expression rather than by altering the genetic code itself. "Epigenetics is a very complex mechanism of gene regulation: it will take some time for scientists to fully exploit it, although there are many There are success stories, "he adds. Tests for the selection of potentially antagonistic tumors, but also of agents with proven epigenetic activity and solid ones

Data to choose the most effective dose and schedule

"Some technical issues still need to be addressed preclinical and clinical settings ̵

1; for a long time

" Epigenetic drugs are among a category of drugs used to treat specific cancers and divide into two groups: DNA methylation inhibitors and histone deacetylase inhibitors, "says Herbst.

Gene Functions

"As far as I know, the US Food and Drug Administration [FDA] has so far approved seven drugs for the treatment of cancer.

" Epigeneti c therapy … refers to the use of these drugs to reverse certain gene functions that are more likely to be disturbed in non-cancerous cells, by targeting epigenetic pathways to alter the course of a particular cancer.

Regarding epigenetic drug treatment and a class of enzymes called histone deacetylases, an article published in Experimental and Clinical Sciences Excli Journal defines histone acetylation as a "modification … by the opposite action of two families of histone-interacting Proteins, the histone acetyltransferases that "write" on them regulate chromatin and histone deacetylases, which "erase" the writing and reverse its action on the genome.

"Methylated DNA represents a docking point for methyl-binding proteins … recognized by other histone-modifying enzymes that regulate transcription, DNA repair, and replication."

The FDA has approved azacitidine and decitabine Treatment for blood cancer approved The DNA methylation inhibitors have proven to be successful.

Epigenetic therapy has been shown to work in conjunction with chemotherapy and targeted therapy. Italian neuroscientists Gerardo Caruso and Maria Caffo found in a study that "data suggest that low-dose treatments with epigenetic targeting agents will prove to be the next breakthrough in cancer treatment" using "clinically relevant doses" do not cause cytotoxicity "[cell poisoning].

"Most notable from this study is that the seven ovarian cancer patients included in the study either all achieved either partial responses or disease stabilization.

Epigenetic drugs in combination with standard chemotherapy have also emerged have been shown to be effective in the treatment of prostate cancer and bladder cancer, but showed "mixed results" in the treatment of renal cancer.


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