Moderate exercise may help patients taking cholesterol-lowering statins to overcome the most common side effect of muscle pain.
- About six million people in the UK take statins at a cost of £ 20 per patient.
- Between 15 and 20% of the Patients Taking It Report Some Form of Muscle Pain
- Discovery May Cause Dozens of Patients to Stop the Medication
Moderate stress may, according to researchers, be the antidote to the most common side effect of statins.
Thousands of patients who experience cholesterol busting pills make muscle pain after taking the medication.
And scientists now claim they know why, which could lead to a breakthrough that could result in fewer patients losing life-saving medicines.
Thousands of Patients Taking the Cholesterol Busting Pills Muscle Pain After Taking the Medication
About six million people in the UK take statins, preventing 80,000 heart attacks and strokes per year at a cost of around £ 20 per patient ,
Many others start taking the medication, but stop – between 15 and 20 percent of patients report muscle pain.
Doctors believe that tens of thousands of people die every year in Britain because they avoid life-saving pills, often because of side effects.
Researchers from the University of Leeds and the Karolinska Institute in Sweden found that statins can cause spontaneous calcium leakage from storage compartments in muscle cells.
Unregulated calcium leaks can damage muscle cells and possibly lead to muscle pain and weakness.
In most cases, muscle cells can tolerate this calcium leak, as funded by the British Heart Foundation.
But in people who are already vulnerable to their genes or lifestyle, muscle cells can become overwhelmed, causing muscle pain and weakness.
WHY ARE STATINS EFFICIENT?
Statins are the world's most widely prescribed drug, and an estimated 30 percent of adults over the age of 40 are allowed to take them.
The cholesterol-lowering drugs are administered to individuals with an estimated 10% or greater risk of developing cardiovascular disease, heart attack, or stroke within the next 10 years.
It has been proven to help people who have suffered from heart problems in the past. However, experts say the thresholds may be too high. This means that the benefits for many people are outweighed by side effects.
Almost all men exceed the threshold of 10 percent to 65, and all women do so until age 70, regardless of their health.
Common side effects include headache, muscle aches, nausea, and statins can also increase the risk of type 2 diabetes, hepatitis, pancreatitis, and vision problems or memory loss.
Research published in the Pharmaceutical Journal last year showed that taking statin daily f or five years after a heart attack has prolonged your life by just four days.
And dr. Rita Redberg, a professor at the University of California, San Francisco, told CNN in January that 100 people have been on statin for five years. After a heart attack or stroke, one or two people are estimated to have a heart attack by taking statins avoid and no person live longer muscle pain after taking statins.
The researchers also showed that physical activity can prevent the occurrence of changes that lead to calcium leakage.
And it could be an effective way for people taking statins to avoid muscle symptoms, she wrote in JACC: Fundamentals of Translation Science.
The team investigated the effect of statins on muscle biopsies in patients taking statins over a longer period of time and on statin-treated rats for four weeks.
They found a statin compromise d Gatekeeper proteins, called ryanodine receptors, control calcium release from the storage compartments of muscle cells.
This resulted in spontaneous and irregular calcium leaks that could trigger signals that promote cell death in both humans and rats treated with statins compared to untreated controls.
Despite the cell changes, the statins had no effect on the muscle function or strength of the rats.
They said the investigations also suggest the potentially harmful effects effects of statins on the musculature can be counteracted with exercise.
When rats were given free access to exercise, the statin-induced changes in gatekeeper proteins no longer occurred.
The research team also observed that statin-treated rats were twice as likely as control rats.
Professor Metin Avkiran, Deputy Medical Director at BHF, said: "Statins are life-saving medicines and most people take them they have no side effects.
& # 39; Those who suffer from muscle pain and muscle weakness should always ask their doctor if another statin or dose could solve the problem.
& # 39; It's the first question of how statins affect muscle cell biology Steps to prevent potential muscle side effects – and to make sure that people who are prone to these side effects do not miss the protection of statins.
The researchers stated that they have not directly shown that cell changes lead to muscle weakness and pain in humans, but note that this is likely.
The proposed mechanism may also explain why myocardium, which contains various gatekeeper proteins for calcium release, is protected from potentially deleterious effects.
HOW MUCH EXERCISE MUST YOU DO?
In order to stay healthy, adults aged 19 to 64 years should try to be active daily walking every week and
- strength exercises on 2 or more days a week, covering all major muscles (legs, hips, back, Stomach, chest, shoulders and arms).
- 75 minutes of vigorous aerobic activity such as running or a game of single tennis every week and
- strength exercises on two or more days a week during which all the major muscles (legs, hips, back, stomach,
- A mix of moderate and vigorous aerobic activity per week – for example, 2 x 30-minute runs plus 30 minutes of brisk walking equals 150 minutes of moderate aerobic activity and
- strength exercises 2 or more days a week training all major muscles (legs, hips, back, stomach, chest, shoulders and arms)  A good rule is that 1 minute of intense activity provides the same health benefits as 2 Minutes of moderate activity.
One way to perform your recommended 150 minutes of weekly physical activity is to spend 30 minutes on 5 days a week.
All adults should also interrupt long periods of sitting with mild activity.