Personal belongings by Stephen Hawking, including a signed copy of his 1
In total, 22 items owned by Christie's physicist, who died in March, are sold over nine days.
They contain an early wheelchair and a script for a performance by Prof. Hawking at The Simpsons.
A specialist said the items represented the "ultimate triumph of scientific brilliance over adversity."  The extraordinary thesis that was signed twice and by the scientist in the year in which he diagnosed with a motor neurone disease was enrolled, is expected to reach £ 150,000.
The sale includes medals, awards and scientific work.
Prof. Hawkings book A Short History of Time, which he signed in 1988 with a thumbprint, is directed at 2,000 to 3,000 pounds.
Physicist's daughter, Lucy, said Christie's helped the family manage "our beloved father's unique and valuable collection of personal and professional belongings."
The "earliest surviving example" of one of Prof. Hawking's motorized wheelchairs, which he used from the late 1980s to the mid-1990s, was able to raise up to £ 15,000 for charity.
proceeds from the sale of the red leather The chair with a footrest will go to the Stephen Hawking Foundation and the Motor Neurone Disease Association.
Sophie Hopkins, Christie's specialist in manuscripts and archives, said much of the collection was "incredibly iconic."
"Once Hawking realized that his diagnosis was not a death sentence, he continued his work with a new sense of power," she said.
"It is the ultimate triumph of scientific brilliance over adversity."
"Alone his book has become an excellent reference to his true mind – the ability to make something so complicated accessible to everyone.
The online sale called "On the Shoulders of the Giants" also contains rare signed works by Einstein, Darwin and Sir Isaac Newton.