Hawking, a wheelchair user suffering from motor neuron disease using an electronic speech synthesizer, died at the age of 76 in March.
"On the Shoulders of Giants", which also contains documents by Isaac Newton, Charles Darwin and Albert Einstein, will contain 22 lots from Hawking's estate, including one of five known copies of his doctoral thesis, "Properties of expanding univeres" at 100,000-150,000 pounds ($ 127,480) – $ 191,220).
"Stephen Hawking was a great person worldwide, and had this amazing ability to connect with people," said Thomas Venning, director of books and manuscripts at the Christie's auction house in London, Reuters.
"The whole idea … was to offer something that was accessible to its admirers so that people could connect with it and remember its extraordinary story."
For sale is also a copy of Hawking's bestseller "A Brief History of Time", which was signed with his estimated thumbprint between 2000 and 3000 pounds thumb and the awards and medals awarded to the scientist with a price of 10,000 – 15,000 pounds.
Additional documents, an invitation for a "Time Travelers" reception, and a motorized wheelchair used by Hawking will also be sold in the online auction from October 31 to November 8.
According to Venning, it has already attracted interest from Asia, the Middle East, the United States and Australia.
"(Hawking) traveled the world and he has fans in the US, he has fans in Asia," he said.
(Report by Hanna Rantala, Letter from Marie-Louise Gumuchian, Editor: Mark Heinrich)