Wrinkles are not only a sign of aging in our external appearance, but can also occur deep inside at the cellular level. Wrinkles in the cell nuclei of our cells can affect certain genes and contribute to diseases such as fatty liver. Balancing these wrinkles could be the answer.
In a study published online in Aging Cell researchers from the School of Medicine of the University of Virginia noted that as cells age, their nuclei or the cell center can also become wrinkles similar to those develop in the aging skin. The nucleus occupies about 10 percent of the cell volume and also contains our DNA. As a result, wrinkling can affect gene expression and lead to more serious health problems, including Type 2 diabetes and cardiovascular disease, which can lead to death, MedicalXpress reported.
Not all genes are equally affected by this wrinkling. Although every cell in our body has the same genes, whether they are on or off, whether the genes work. The study found that genes that were switched off were pressed more tightly against the nucleus and were therefore more affected by cell nucleus folds.
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This finding is particularly problematic for the liver because with age the nuclear membranes of our liver can become fat-laden. This fat causes the cell membrane to wrinkle and affect the genes that are pressed close to it. [1
"If your nuclear membrane no longer works properly, it can release the DNA that needs to be turned off," said Irene M. Bochkis from the UVA Department of Pharmacology, MedicalXpress reported: "Then your little liver cell will become a small fat cell."
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Wrinkling is caused by the lack of a substance called lamin, which not only points out what happens when the cell nuclei fold, but Also, How This Wrinkling Could Be Reversed This laminate may be able to reverse some of the wrinkling and, in turn, prevent gendysia, which could be particularly important for research into potential treatments for fatty liver disease.
Nonalcoholic fatty liver disease is a condition characterized by the presence of fat in more than five percent of liver cells, Harvard Health reported. Drinking too much alcohol can cause fat to accumulate in the liver, but in this case it is caused by other factors such as high blood pressure or diabetes.