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Home / Science / Substance in the species of moss found to have similarities with THC, perhaps more "medically effective" than cannabis

Substance in the species of moss found to have similarities with THC, perhaps more "medically effective" than cannabis



Liver mosses are a group of about 9000 species of spore-producing plants. They are distributed around the world but are much more common in tropical areas. ( University of Bern )

It is discovered that one type of moss is potentially "medically more effective" than cannabis, with less psychoactive high. It is marketed online as a "legal high".

& Legal High & # 39;

It has long been recognized that cannabis is the only plant that produces tetrahydrocannabinol (THC), which is used by many to treat various substances. B. Dizziness, loss of appetite and pain, but it is still considered an illegal narcotic and can cause side effects cause. This is because THC has a strong psychoactive effect when used in higher doses.

It was in 1

994 when Japanese phytochemist Yoshinori Asakawa discovered that the liverwort plant Radula perrottetii actually contains a substance that resembles THC but differs in three-dimensional structure and has an additional benzyl group. He called it Perrottetinen.

Several years ago Dr. Jürg Gertsch from the University of Bern found out that liverwort was advertised online as a "legal high", although at that time no information was known about its pharmacological properties.

More & # 39; medically effective & # 39; As THC

Now animal model studies by Gertsch's research team, along with a research team from ETH's Department of Chemistry, THC and Perrottitines, discovered that perrotetins can actually reach the brain easily and trigger or activate cannabinoid receptors in the same way as the natural endocannabinoids of the body. They further found that the substance has an even stronger anti-inflammatory effect in the brain compared to THC and with a weaker psychoactive effect.

By comparison, THC is therapeutically effective in treating various conditions in low doses, but has severe psychoactive effects in higher levels. For this reason, although THC is effective for some, it is still not used by many. Put simply, it is possible that perrotetins are "more medically effective" than THC, although more researchers are needed to fully understand its pharmacological potential.

"It's amazing that only two plant species are separated by 300 million years of evolution, producing psychoactive cannabinoids," said Gertsch.

The publication is published in Science Advances .

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