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The GV chickens laying eggs with cancer medicines



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Image copyright
Norrie Russell, The Roslin Institute

Caption

These chickens have a human gene that allows them to lay eggs with beneficial drugs

Researchers have genetically modified chickens that can lay eggs containing medicines for arthritis and some cancers.

Drugs are 1

00 times cheaper than laid in factories when installed.

Researchers believe that timely production can be increased in commercial quantities for drug production.

The chickens do not suffer and are "spoiled" compared to livestock. Lissa Herron of Roslin Technologies in Edinburgh.

"They live in very large stalls and are fed and watered daily by well-trained technicians who live a quite comfortable life.

" As far as the chicken knows, it's just a normal egg. It has no effect on his health, it is just the butt and lay eggs as usual.

Scientists have previously shown that genetically modified goats, rabbits and chickens can be used to produce protein therapies in their milk or eggs, and researchers say their new approach is more efficient, yields better and is more cost effective than this

"The production of chickens can cost between 10 and 100 times less than the factories. So hopefully we'll see at least ten times lower overall manufacturing costs, "said Dr. Herron.

Copyright
Norrie Russell, The Roslin Institute

Caption

Battery Pharming: These eggs contain drugs at one-tenth the cost of one normal production in laboratories

The biggest savings come from the fact that chicken coops are much cheaper to build and operate than high-purity clean rooms for factory production.

Many diseases are caused because the body does not produce enough of a particular chemical or protein. Such diseases can be combated with drugs containing the defective protein. These drugs are manufactured synthetically by pharmaceutical companies and can be very expensive to manufacture.

Dr. Herron and her colleagues were able to cut costs by introducing a human gene that normally produces the protein in humans into the chicken. DNA involved in the production of white in chicken eggs.

No yoke!

After Herron cracked the eggs and separated the whites from the yoke, Herron discovered that the chicken contained relatively large amounts of protein.

The team focused on two proteins that are important for protein Immune system: One is IFNalpha2a, which has potent antiviral and anticancer effects, and the other is macrophage cerebrospinal fluid, which is being developed as a therapy that stimulates damaged tissue to repair yourself.

Three eggs are enough to create a nervous system dose of the drug, and chickens can lay up to 300 eggs a year. With enough chickens, the researchers believe they can produce drugs in commercial quantities.

The development of medicines for human health and the necessary regulatory framework will take between 10 and 20 years. Researchers hope to use chickens to develop animal health medicines.

These include drugs that enhance the livestock's immune system as an alternative to antibiotics, thereby reducing the risk of developing new antibiotic-resistant superbug strains. According to Herron, it is possible to use the healing properties of macrophage CSF for the treatment of pets.

"For example, we could use it to regenerate the liver or kidneys of a pet that has damaged them, and the drugs currently available are a little too expensive, so we hope we may get a little more . "

Professor Helen Sang from the University of Edinburgh's Roslin Institute said," We are not yet manufacturing drugs for humans, but this study shows that chickens are commercially suitable for the production of proteins that are required for drug discovery studies and others Applications in biotechnology are suitable. "

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