As with any form of ban, once the locks open, there is an inevitable surge of surplus. In recent years, ever stronger oils and concentrates have emerged. But as the party smoke becomes clear, it changes. People are exploring various cocktails and new connections with the goal of choosing the effects to achieve exact moods and experiences. This can be as vague as "party" or as specific as lucid dreams. The problem is that we are probably still years (or decades) away from making such claims with a degree of confidence. At least in a way that would be worthy of the FDA's stamp.
Cannabis is a complex plant that we know. "So maybe there are about 140 more cannabinoids or cannabinoids derived from plants, and THC and CBD are the two best studied, but there are at least 130 more," says Piomelli, a professor at the University of California Irvine and co-chair of the Center for the Study of Cannabis in an interview with Engadget.
These are many compounds in a plant about which we do not know much. But that does not stop people from trying. Strains that are high in the other around 130 cannabinoids are not common, but expect this to change in the future. In the meantime, cannabis companies are experimenting in three ways: the ratio of THC to CBD, with terpenes and other elements already in the plant, and with additional non-cannabis additives.
Manipulating cannabis is nothing new. For decades, plants such as dogs have been bred to increase their effectiveness and impact. Anyone who has seen Narcos: Mexico will know that even the famous "Sensimilla" (essentially a "seedless" cannabis plant) is a byproduct of human botanical intervention.
THC is, without a doubt, the star of the cannabis show. It is what has brought mankind to the plant at all. Their effects are unmistakable and for the most part pleasant. CBD is the next known cannabinoid and one that is currently exploding into the mainstream thanks to the recent Farm Bill. It is the balance of these two compounds that gives the first indication that the effects of cannabis can be adjusted.
The Californian company Dosist has six cannabis pens to choose from. Each "formula" is marked with its primary effect (Arouse, Calm, Bliss, etc.). Dosists vaporizers are aimed at people who are looking for relief from pain or insomnia, and not those who want to be baked. Together with a breakdown of the THC / CBD ratios and the complete (handpicked) terpene profiles, the pen will vibrate as soon as you inhale Dosist's optimal level (hence the name). The company's guidelines suggest a maximum of three "cans" per hour barely enough to change your mind, but sufficient for the benefits – at least according to the company.
Terpenes are essential oils that are found in many plants (not just cannabis), they are characteristically strong in smell, and for most people, that's what the taste Your cannabis tap. But some companies, like Dosist, believe that they can have an impact The potency and direction of the effects of cannabis.
Piomelli is more skeptical. "I would say 95 percent of the claims made are essentially unfounded.Tenpenes are compounds.There are biologically active compounds, and there are some terpenes that are particularly active in the cannabinoid system," he says. "But the evidence that a combination of terpenes, that is, a specific terpene, either enhances, diminishes, or otherwise modulates the effects of THC, CBD, and other cannabinoids, the evidence is simply not there. "
That does not mean that the idea is not preferable except that scientific evidence is sparse. "I'm not the one who rejects the whole anecdote evidence when the anecdotal evidence is made by thousands of people," added Piomelli. "There is a point we need to ask ourselves Whether there is so much smoke that there must be fire. "
While cannabinoids and terpenes hold up promising, some think Can nabis needs a helping hand to get you where you want to go. White Fox Atmospheres is one of the growing brands that bring other herbs into the mix, defining its mission as "to formulate and create a specific, effect-oriented medicine."
White Fox's Vape products contain good old-fashioned cannabis, but with " Ayurvedic formulations "in addition. In Ayurvedic medicine, things come even further into the unknown. The formulations are thousands of years old, but there is a lack of definitive scientific research on their medical effectiveness.
Scarlet Ravin, White Fox's founder and CEO, creates the line with the sole intention of making people feel better. Fed with the arms race in cannabis, the zero sum g is incredibly high. She tells Engadget that she wants to answer the question, "How can we make good use of the medicine if we are not just super stoned and blow our heads off?"
The Result There are three different forms of cannabis vape: one for both male and female "sexual energy" and another that promises to improve your ability for lucid dreams. Ravin is aware that people may have certain expectations for a product called "Legendary" or something that contains Valeriana wallichii root, but claims that the effect you get like most holistic remedies is more holistic is.
"So our formula brings people back to this state of inner balance," she says. "And many people who regularly smoke pens will say," I was in pain to see if it worked and I feel like in my body and I feel in my heart when I smoke this pen. & # 39; It's more about a wellness-allover-condition than a kind of "candy", you know?
What about research?
The search for new, specific effects of cannabis is not surprising: Piomelli explains that cannabinoids have a "privileged structure," meaning that they have more of a physiological or pharmacological effect
Understanding relationships, terpenes and the interaction between cannabinoids is the key to an individual cannabis future, according to Jacob Borodovsky, a researcher at the Washington University School of Medicine's Department of Psychiatry, specializing in cannabis and opioid epidemiology "It could be a future that could be a few years away." "I think we'll get to such a place after you and I are long dead," he says, "I think that gets through in medicine first Neurobiology is happening and we will start to understand these things much better. "
Borodovsky refers in part to the la slow pace with which science can study such things. The number of required studies is large – far greater than the available financial resources. Cannabis is now a commercial venture and patenting is difficult. Piomelli agrees: "It will cost many millions of dollars because you need a large number of subjects and need your placebo controls, it's an expensive company, and no company is interested in it, because how would they protect their property after that?"
From time to time, however, we have enough evidence to turn a medicine into a drug. Epidiolex is a CBD-based drug that has recently received FDA approval for the treatment of Dravet's disease (a severe form of epilepsy in infants).