Of those infected, 21 were hospitalized. No deaths were reported. The infected people are between the ages of 1 and 84 years and the average age is 18 years.
The cases include people who have eaten beef since March 1, the agency said, but no vendor, distributor or brand beef was identified.
"Traceability investigations are underway to detect the source of raw ground beef served in grocery stores and restaurant locations where ill patients reported food," the CDC said.
"Diseases that occurred after March 29 may not have been reported yet, as there is a time between the illness of a person with E. coli and the reporting of the disease, which lasts on average two to three weeks", said the researcher CDC.
States affected by the eruption are Georgia, Kentucky, Ohio, Tennessee, Virginia, Indiana, Florida, Illinois, Mississippi and Minnesota.
There is no clear link between these products and the ongoing outbreak of E. coli, says the agency.
Symptoms of E. coli infection include severe stomach cramps, diarrhea, and vomiting. They start on average three to four days after the bacteria are taken. Most people recover after five to seven days.
Consumers are encouraged to prevent the spread of E. coli by frequently washing their hands, cooking minced beef to an internal temperature of 160 degrees, and keeping uncooked foods away from raw beef. Contamination.
CNN's Faith Karimi contributed to this report.