A Washington State University research team has developed a drug delivery system using curcumin, the main constituent of spice curcuma, which successfully inhibits bone cancer cells while promoting the growth of healthy bone cells.
The work could lead to better postoperative treatments for people with osteosarcoma, the second most common cause of cancer death in children.
Researchers, including Susmita Bose, Herman, and Brita Lindholm, endowed professor at the School of Mechanical and Materials Engineering, and doctoral student Naboneeta Sarkar report on their work in the journal ACS Applied Materials and Interfaces .
Young patients with bone cancer are often treated before and after chemotherapy with high doses surgeries, many of which have harmful side effects. Researchers want to develop smoother treatment options, especially after surgeries when patients are trying to recover from bone damage while also taking sharp drugs to suppress tumor growth.
Turmeric has been used for centuries in the kitchen and as a medicine In Asian countries it has been shown that curcumin with its active ingredient possesses antioxidant, anti-inflammatory and bone-forming properties. It has also been shown to prevent several forms of cancer.
"I want people to know the beneficial effects of these natural compounds," Bose said. "Natural biomolecules derived from these herbal products are inexpensive and a safer alternative to synthetic drugs."
However, if taken orally as a medicine, the compound can not be well absorbed by the body. It is metabolized too fast and eliminated.
In their study, researchers used 3D printing to build calcium phosphate scaffolds. While most implants are currently made of metal, such ceramic frameworks, which are more like real bones, could one day be used as a graft material after a bone cancer operation. The researchers incorporated curcumin, which is encased in a vesicle of fat molecules, into the scaffold to facilitate the gradual release of the chemical.
The researchers found that their system inhibits the growth of osteosarcoma cells by 96 percent after 1
"This study ushers in a new era of integration in which modern 3D printing technology is associated with the safe and effective use of alternative medicine, which may be a better tool for bone tissue engineering," said Bose.
unique research area and explore the benefits of integrating other natural compounds into biomedical technology.
Natural remedies in combination with biomedical devices promote bone health and bone growth
Naboneeta Sarkar et al., Liposome-encapsulated, Curcumin-loaded 3D Printed Scaffold for Bone Tissue Engineering, ACS Applied Materials & Interfaces (2019). DOI: 10.1021 / acsami.9b01218
Temporal Release of Turmeric Stops Cancer Cell Growth (2019, June 20)
retrieved on June 20, 2019
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