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UCSF study proposes novel treatment for the prevention of chronic age-related diseases: moisturizer






A new UCSF pilot study provides a simple suggestion for treatment to address age-related problems such as Alzheimer's, diabetes and heart disease. The best part? You could already own it.

University researchers and the San Francisco Veterans Administration (VA) Health Care System now have reason to believe that inflammation of the skin may promote the emergence of multiple chronic conditions and may be a way to eliminate disorders Application of a reparative moisture storage.

The authors of the study report that when the skin loses moisture and begins to lose moisture at the age of 50, the skin undergoes a collapse of the "permeability barrier". The barrier is designed to hold water in the body as well as to protect against harmful pathogens outside our body.

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When this barrier weakens with age due to moisture loss, it sets cytokines (a type of protein) released by cells of the immune system) to signal inflammation in the age-affected regions of the skin. Normally, such cytokines should help to repair the barrier, but older skin requires more effort to repair it, the researchers write so that the skin releases these "inflammatory signals" repeatedly. Finally, the cytokines can invade the blood and possibly cause inflammation throughout the body.


Previously, the researchers had not suspected that the skin could be to blame for promoting such diseases, but recent studies have pointed to the possibility of skin inflammation can be blamed for heart disease.

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"Inflammation must come from an organ that is so large that a very small inflammation can affect the entire body Size is a good candidate for it, "said the older author of the study. Qiang Man. "Once we are old, we have dermatological symptoms such as itching, dryness, and altered acidity, it could be that the skin has very little inflammation, and because it is such a large organ, it increases circulating cytokine levels."

The UCSF The study was conducted in 33 adults between the ages of 58 and 95 years. They were given a type of moisturizer that researchers had identified for their ratio of three lipids known to be beneficial to skin health. Participants were instructed to apply the moisturizer twice a day for one month to the whole body. Afterwards, the doctors found that their cytokine levels are almost identical to those of the 30-year-olds, suggesting that the skin can be counteracted by rejuvenating the inflammation. "


The scientists will then follow up their initial results with a long-term study to test the effects of using the moisturizer, and if the findings are similar, this may be confirmation of the degradation of a reparative moisturizer as an effective means of warding off chronic disease.

Alyssa Pereira is a writer at SFGATE Send an e-mail to apereira@sfchronicle.com or find it on Twitter at @alyspereira .


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