UPS has received state approval to operate a nationwide fleet of drones.
The company can begin to expand supplies to hospitals and eventually move closer to lead to deliveries to consumers.
But before UPS or other operators can deploy the drones, there are many regulatory hurdles.
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The Federal Aviation Administration awarded UPS a certificate this past week as the first US company to do so.
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UPS Flight Forward, a subsidiary, has performed more than 1,000 flights on the WakeMed Hospital campus in Raleigh, North Carolina.
UPS still faces stringent restrictions on how to run a large commercial operation with rones.
Operation will be limited to campus-like settings as the FAA has not yet issued regulations for commercial drone flights over populated areas.
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Transportation Minister Elaine Chao called the move a step forward in integrating drones into US airspace and maintaining US leadership in unmanned aerial space.
The Associated Press contributed to this article.