The ship, which was not marked, was described as Dhau, a small sailboat common in the region. The official added that the number of seized weapons could exceed 1,000.
The boarding was conducted by the crew of the destroyer USS Jason Dunham of the Arleigh Burke class, which was involved in an operation of the US Naval Forces Central Command.
The Dhow crew allowed the US Navy to respond at their request.
The officer said the ship's target was not immediately clear, although US officials said that ships intercepted in the past had been linked to Iranian efforts to support the Houthi rebels in Yemen
determining the origin and destination of the boat on board, said the official
The US is supporting the coalition led by Saudi Arabia in their fight against Iranian-backed Houthis, a conflict heightened in the face of concerns over civilian casualties under the microscope.
The Gulf of Aden, which links the Indian Ocean with the Red Sea, sees heavy shipping traffic and is often used by smugglers to carry a variety of freights
US and Allied warships take part in the Combined Task Force 150 some previously intercepted other ships in the area. In April, a French frigate seized thousands of pounds worth of illegal drugs worth several million dollars.