The neurodegenerative disease is an umbrella term for a number of states that mainly affect the nerve cells that are the building blocks of the nervous system. Neurons do not usually reproduce or replace themselves, so if damaged or dying, they can not be replaced by the body. Researchers at Kazan University have demonstrated that water-soluble polyol methanofullerenes can reduce mitochondrial transmembrane potential. This makes them promising in the development of targeted mitochondrial drugs and composites based thereon.
There is currently no doubt that the hyperpolarization of mitochondria and the associated oxidative stress associated with the development of severe pathologies such as Alzheimer's, some cancers, and other conditions.
Hyperpolarized mitochondria have an increased transmembrane potential due to the excess of H + ions in the intermembrane space compared to the matrix. Protonophores reduce mitochondrial potential by facilitating the electrogenic transport of protons through the inner mitochondrial membrane.
It is also described that water-soluble polyol methanofullerenes are soft protonophores, since they can only take up H + ions in hyperpolarized mitochondria and can not penetrate into normally polarized mitochondria
The results are published in the journal Bioorganic & Medicinal Chemistry Letters published.
Released: April 1