You know the story. Guy extracts dinosaur DNA from fossilized mosquitoes. Dinosaur eggs hatch. A prehistoric theme park is emerging and is becoming a major burden. Dinosaurs live on.
Even if this is not the case, it is still uncanny how scientists have now been able to reactivate the cells of a woolly mammoth that died more than 28,000 years ago. Similar to the Dino DNA in Jurassic Park was injected into oocytes of frog cells or oocytes. Mammalian cell nuclei were injected into oocytes from mice in a process known as nuclear transfer. They managed to temporarily survive, which has now proven that the genes of extinct creatures can be – if only for a moment ̵
A team of Japanese researchers around the biologist Kazuo Yamagata was able to extract viable genetic material from a young woman's woolly mammoth known as Yuka. It was discovered in 2010 under the permafrost on the coast of the Strait of Dmitry Laptev in the extreme east of Russia. While the corpse lacked many vital bones and organs, there was still enough material in which its genetic code had been preserved since the last ice age.
"Ancient species contain invaluable information about the genetic foundations of adaptive evolution and related extinction factors," said Yamagata and his colleagues in a recent study published in Nature
. Yamagata and his team had previously tried to resurrect mammal cells – from a nearly half-year-old mummified specimen as Yuka – but were unsuccessful. Yuka was in such an amazing state, at least for something that had smelt in the ice for almost thirty centuries, that they were able to extract nuclei from their muscle tissue and implant them into mouse oocytes. They turned into zombie cells. Art.
The mammalian cells were unable to divide, which is crucial for producing a true mammoth embryo, but it is almost astonishing that they were able to make it through some stages of division. They went all the way to spindle assembly, a process whereby chromosomes are correctly attached to spindle structures before a cell breaks down.
A cell division that fails a mummy raises the question of whether a de-extinction (at least in species that have won) Try to eat us alive, as some of the gigantic lizards in Jurassic Park) it really be possible.
"The results presented here clearly show us the factual impossibility of cloning the mammoth with the current technology to [nuclear transfer]." Yamagata admitted, but the "approach paves the way for assessing the biological activities of nuclei in extinct species."
So maybe we will not soon see any Ice Age park, but even the cells of sentient beings have gone the way of the mammoth, science fiction has been brought to life.